Table 3.
Patient # | Presenting Stroke Subtype |
Initial NIHSS | Diagnosed IE at Stroke Presentation | Pathogen | Intervention | Follow-Up Imaging | Outcome (mRS) | ||
---|---|---|---|---|---|---|---|---|---|
Ischemia | ICH | SAH | |||||||
1a | X | 15 | No | S viridans | IV-tPA | HT (ICH) | 5 | ||
2 | X | X | 4 | Suspected | S viridans | None | Expected evolution | 6 | |
3a | X | 16 | Suspected | E faecalis | None | Expected evolution | 4 | ||
4 | X | 13 | Yes | P aeruginosa | None | Expected evolution | 6 | ||
5a | X | 14 | No | Coag-neg Staph | IA-tPA, Merci | HT (ICH), SDH | 6 | ||
6 | X | 1 | Suspected | None identified | None | Not done | 0 | ||
7 | X | 2 | No | S lugdunensis | None | Not done | 1 | ||
8 | X | X | – | No | MSSA | None | New ischemia, HT (ICH + IVH) | 5 | |
9a | X | 8 | No | E faecalis | IV-tPA | ICH, SAH | 6 | ||
10a | X | 14 | No | E Faecalis | IV-tPA, Merci | HT (ICH + IVH), SAH | 6 | ||
11 | X | X | 14 | No | None identified | None | New ischemia | 6 | |
12 | X | X | 20 | Yes | None identified | None | Expected evolution | 6 | |
13b | X | X | – | Yes | Staphylococcus | IA-tPA, angioplasty | Expected evolution | 6 | |
14 | X | 19 | No | Enterococcus | None | Expected evolution | 4 | ||
15 | X | 1 | Yes | S milleri | None | SDH | 1 | ||
16 | X | X | – | No | MSSA | None | Expected evolution | 6 | |
17 | X | 14 | Suspected | None identified | None | New ischemia, HT | 6 | ||
18 | X | 9 | No | MSSA | None | Expected evolution | 4 |
Abbreviations: Coag-neg Staph, coagulase-negative Staphylococcus; E faecalis, Enterococcus faecalis; HT, hemorrhagic transformation; IA-tPA, intra-arterial tissue plasminogen activator; ICH, intracranial hemorrhage; IV-tPA, intravenous tissue plasminogen activator; IVH, intraventricular hemorrhage; mRS, modified Rankin Scale; MSSA, methicillin-sensitive Staphylococcus aureus; NIHSS, National Institute of Health Stroke Scale; P aeruginosa, Pseudomonas aeruginosa; S lugdunensis, Staphylococcus lugdunensis; S milleri, Streptococcus milleri; S viridans, Streptococcus viridans; SAH, subarachnoid hemorrhage; SDH, subdural hematoma.
a Presented within 6 hours of stroke symptom onset.
b This patient had known endocarditis and a minor SAH on presentation, but after discussion with the family and in the setting of a disabling left middle cerebral artery stroke, he received IA-tPA and angioplasty. This restored blood flow without worsening SAH on follow-up imaging, but he never regained consciousness and died 3 days later.