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. 2013 Jul 1;123(8):3211–3230. doi: 10.1172/JCI65521

Figure 7. Jagged1 overexpression enhances tumorigenicity in APEX1-depleted DLD1 and KM12SM cells.

Figure 7

APEX1-shRNA/DLD1 and APEX1-shRNA/KM12SM cells were transfected with control vector or Jagged1 expression vector. (A) Cell growth. Lysates of cells were examined for Jagged1 and APEX1 expression by Western blot analysis. (B) Colony formation in soft agar after 14 days of culture. (C) Cell migration and invasion. (D) Tube formation assays were performed by culturing HUVECs in tube formation with supernatants from the indicated cells. Results in A–D are mean ± SD (n = 3). **P < 0.01. Scale bars: 100 μm (B); 40 μm (C); 80 μm (D).