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. 2013 Jul 1;123(8):3211–3230. doi: 10.1172/JCI65521

Figure 8. APEX1 regulates tumor growth through Jagged1 in a mouse model.

Figure 8

(A and B) The indicated DLD1 cells were implanted subcutaneously in nude mice (n = 6). (A) Photographs of representative mice and tumors (each condition was independently repeated 3 times) and immunofluorescence analysis of APEX1 and Jagged1 in tumors. (B) Growth curves of mammary tumors after implantation. (C and D) The indicated SW480 cells were injected into the right flank of nude mice (n = 6). (C) Photographs of representative mice and tumors and immunofluorescence analysis of APEX1 and Jagged1 in tumors. (D) Growth curves of mammary tumors after injection. Results in B and D are mean ± SD (n = 6). Scale bars: 40 μm (A and C).