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. 2013 Jul 1;123(8):3436–3445. doi: 10.1172/JCI66549

Figure 1. Endothelial ANG2 overexpression induces pericyte loss and increased vascular permeability.

Figure 1

(A) Inducible endothelial ANG2-overexpressing mice (EC-ANG2-on mice) develop enlarged lips (red arrow), (B) enlarged ear vessels (scale bar: 200 μm), and (C and D) increased permeability for 4-kDa TRITC-dextran (scale bar: 50 μm; n = 4). (E–G) Cardiac capillary density (PECAM-1 staining) and pericyte coverage (NG2 staining) are decreased in EC-ANG2-on mice (n = 5 for EC-Control and EC-ANG2-on, n = 4 for EC-ANG2-off). Scale bar: 50 μm (E); 5 μm (F). *P < 0.05, **P < 0.001.