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. 2013 Jul 1;123(8):3436–3445. doi: 10.1172/JCI66549

Figure 3. Cardiomyocyte-specific ANG2 overexpression does not induce peripheral microcirculatory and hemodynamic alterations.

Figure 3

(A and B) Cardiomyocyte-specific ANG2 overexpression (CM-ANG2-on) reduces pericyte coverage (NG2 staining) of capillaries (PECAM-1 staining) in cardiac but not skeletal muscle (scale bar: 5 μm; n = 5). (C) Systemic mean arterial pressure (n = 6) and (D) LV developed pressure is normal in 24-week-old CM-ANG2-on mice (n = 6 per group). (E) CM-ANG2-on mice display normal LV end-diastolic diameter (n = 6). (F) Minimal fibrosis was detected in CM-ANG2-on hearts. Scale bars: 1,000 μm (Lens); 200 μm (×10); 50 μm (×40). (G) HW/BW ratio was unaffected in CM-ANG2-on mice (n = 6). *P < 0.05.