Figure 6. Aging-associated functional cardiac alterations were not restored by rapamycin treatment.

Key findings of a comprehensive assessment of cardiac function using echocardiography (young control, n = 10; 26-month vehicle, n = 17; 26-month rapamycin, n = 10). (A) Ejection fraction. (B) Fractional shortening. (C) Flow velocity across the aortic valve. (D) Pressure gradient across the aortic valve. (E) Flow velocity across the pulmonary valve. (F) Pressure gradient across the pulmonary valve. Whisker plots display minimum, 25th percentile, median, 75th percentile, and maximum. P values and fit coefficients with 95% confidence intervals are shown; statistically significant differences (P < 0.05) are denoted by bold font.