Table 2.
Descriptive characteristics of FDRs by RF and HRP positivity in FDRs from the Studies of the Aetiology of Rheumatology (SERA) cohort
| RF+ FDRs (n=28) | RF− FDRs (n=78) | p Value* | HRP+ FDRs† (n=25) | HRP− FDRs† (n=81) | p Value* | |
|---|---|---|---|---|---|---|
| Mean age | 53.2±18.4 | 49.1±17.8 | 0.305 | 47.3±18.5 | 51.1±17.8 | 0.359 |
| Sex (% female) | 75 | 76.9 | 0.837 | 80 | 75.3 | 0.629 |
| Ethnicity (% NHW) | 78.6 | 78.2 | 0.968 | 80 | 77.8 | 0.814 |
| Smoking status (% ever) | 28.6 | 41 | 0.244 | 28 | 40.7 | 0.251 |
*
p Values were obtained from t-tests for age and χ2 tests for proportions.
†
High Risk Autoantibody Profile (HRP) is defined as positivity for anti-CCP2 and/or two or more RF isotypes, and has been shown in prior work using preclinical RA samples to be >96% specific for future RA.
FDR, first-degree relatives; NHW, non-Hispanic White; RA, rheumatoid arthritis; RF, rheumatoid factor.