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. 2013 Jul 26;54(7):5097–5102. doi: 10.1167/iovs.13-12157

Figure 2.

Figure 2

SIRT1-KI and SIRT1-KO mice have altered SIRT1 expression in retina. (A) Western blot of protein extracts from retinas of SIRT1-KI mice and wild-type littermates. Blots of three representative eyes are shown. (B) SIRT1 expression, normalized as a ratio to β–actin levels, is significantly increased in SIRT1-KI retina (***P < 0.001). (C) Western blot of protein extracts from retinas of homozygous SIRT1-KO mice and wild-type littermates. Blots of three representative eyes are shown. (D) SIRT1 expression, normalized as a ratio to β–actin levels, is significantly decreased in SIRT1-KO retina (*P < 0.05).