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Model. A, Upon activation by nutritional well being, ASI releases DAF-7 TGFβ. Binding of TGFβ to its receptor DAF-1 in RIM and RIC neurons inhibits RIM and RIC's role in releasing hunger signals. In the absence of hunger signals worms become satiated and quiescent. B, When food is not available, DAF-7 is not released therefore RIM and RIC are activated to release hunger signals. C, A satiety circuit to control appetite in worms. D, Dwelling; Q, quiescence.
