Table 2.
Important gene tragets induced by butanol
| Gene ID | Butanol vs. Control at 24 h | Butanol vs. Control at 48 h | Butanol vs. Control at 72 h | Description |
|---|---|---|---|---|
|
Cell envelope | ||||
|
sll0034 |
2.52 |
1.54 |
1.86 |
D, D-carboxypeptidase |
|
sll0286 |
2.33 |
1.90 |
1.55 |
Uncharacterized N-acetyltransferase |
|
sll0886 |
1.88 |
1.78 |
2.79 |
UDP-N-acetylglucosamme-peptide N-acetylglucosammyltransferase- |
|
sll1053 |
3.52 |
4.00 |
12.12 |
Membrane fusion protein mtrc precursor, putative |
|
sll1395 |
1.91 |
2.61 |
1.54 |
dTDP-6--6-deoxy-L-mannose-dehydrogenase |
|
sll2010 |
1.60 |
1.78 |
2.89 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase |
|
slr0528 |
2.52 |
1.91 |
2.45 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase |
|
slr0993 |
1.75 |
2.33 |
4.21 |
Putative peptidase |
|
slr1166 |
2.86 |
1.68 |
2.36 |
UDP-glucose:tetrahydrobiopterin glucosyltransferase |
|
slr1196 |
4.07 |
1.91 |
2.74 |
Periplasmic protein, function unknown |
|
slr1744 |
1.89 |
1.92 |
2.42 |
N-acetylmuramoyl-L-alanine amidase, periplasmic protein |
|
slr2015 |
3.56 |
4.15 |
2.39 |
Type 4 pilin-like protein, essential for motility |
|
slr2016 |
4.40 |
1.71 |
1.71 |
Type 4 pilin-like protein, essential for motility |
|
Central intermediary metabolism | ||||
|
sll0646 |
4.03 |
1.87 |
1.96 |
Guanylyl cyclase |
|
slr0288 |
1.65 |
2.28 |
2.58 |
Glutamate--ammonia ligase |
|
slr0899 |
2.19 |
2.75 |
2.50 |
Cyanate lyase |
|
slr0940 |
3.33 |
1.96 |
4.21 |
Zeta-carotene desaturase |
|
slr1254 |
1.73 |
1.76 |
4.43 |
Phytoene dehydrogenase (phytoene desaturase) |
|
slr1877 |
6.00 |
3.15 |
3.75 |
2-hydroxyhepta-2, 4-diene-1, 7-dioate isomerase |
|
Common stress response | ||||
|
sll0248 |
3.60 |
3.67 |
1.86 |
Flavodoxin |
|
sll1388 |
3.21 |
1.58 |
1.82 |
Universal stress protein |
|
sll1988 |
1.90 |
1.53 |
1.81 |
33 kDa chaperonin |
|
slr0093 |
2.61 |
1.53 |
2.61 |
DnaJ protein, molecular chaperone |
|
slr1795 |
2.43 |
1.71 |
2.16 |
Peptide methionine sulfoxide reductase |
|
slr1828 |
3.38 |
3.33 |
11.00 |
Ferredoxin, petF-like protein |
|
slr1846 |
1.53 |
2.25 |
4.71 |
Uncharacterized monothiol glutaredoxin |
|
slr1854 |
4.09 |
1.59 |
4.38 |
General stress protein 18 (gsp17 ) |
|
slr2047 |
2.06 |
1.65 |
1.62 |
Phosphate starvation-inducible protein |
|
ssl2250 |
6.00 |
2.00 |
5.00 |
Bacterioferritin-associated ferredoxin |
|
Protein fate | ||||
|
sll0616 |
4.19 |
1.88 |
3.54 |
Preprotein translocase SecA subunit |
|
sll0716 |
3.50 |
3.00 |
1.83 |
Probable signal peptidase I-1 |
|
slr0835 |
1.87 |
2.17 |
6.92 |
MoxR protein homolog |
|
slr0994 |
2.22 |
1.62 |
2.30 |
Octanoyltransferase |
|
slr1046 |
1.86 |
1.75 |
1.50 |
Putative TatA protein |
|
slr1204 |
4.18 |
2.63 |
5.57 |
Putative serine protease HtrA |
|
slr1331 |
2.94 |
2.26 |
3.98 |
Periplasmic processing protease |
|
ssr3307 |
1.76 |
1.63 |
2.04 |
Preprotein translocase SecG subunit |
|
Regulatory functions | ||||
|
sll0043 |
3.20 |
3.20 |
2.21 |
Positive phototaxis histidine kinase |
|
sll0690 |
5.00 |
1.57 |
6.00 |
Probable transcription regulator |
|
slr0640 |
2.28 |
1.86 |
2.20 |
Two-component sensor histidine kinase |
|
slr0780 |
1.84 |
1.70 |
2.33 |
Transcriptional repressor NrdR |
|
slr0947 |
3.18 |
2.38 |
5.44 |
Response regulator for energy transfer from phycobilisomes to photosystems |
|
slr1037 |
3.63 |
2.00 |
3.33 |
Two-component response regulator CheY subfamily |
|
slr1042 |
3.60 |
2.45 |
1.72 |
Two-component response regulator CheY subfamily |
|
slr1414 |
1.54 |
1.67 |
1.66 |
Two-component sensor histidine kinase |
|
slr1531 |
3.00 |
1.83 |
1.55 |
Signal recognition particle protein |
|
slr1805 |
1.53 |
3.81 |
4.66 |
Two-component sensor histidine kinase |
|
ssl0707 |
2.67 |
1.93 |
2.78 |
Nitrogen regulatory protein P-II |
|
Storage compound biosynthesis | ||||
|
slr1993 |
8.75 |
1.76 |
4.79 |
PHA-specific beta-ketothiolase |
|
slr1994 |
32.00 |
11.50 |
4.86 |
PHA-specific acetoacetyl-CoA reductase |
|
slr2002 |
3.52 |
2.09 |
2.57 |
Cyanophycin synthetase |
|
Transport and binding proteins | ||||
|
sll0374 |
1.65 |
1.90 |
2.83 |
Urea transport system ATP-binding protein |
|
sll0689 |
2.21 |
1.63 |
3.28 |
Na+/H + antiporter |
|
sll0759 |
3.11 |
1.56 |
6.87 |
ABC transporter ATP-binding protein |
|
sll1041 |
3.74 |
2.50 |
3.43 |
Similar to sulfate transport ATP-binding protein CysA |
|
sll1154 |
1.76 |
2.80 |
3.98 |
NorA |
|
sll1164 |
6.60 |
1.50 |
1.60 |
Uncharacterized transporter |
|
sll1428 |
32.00 |
2.00 |
7.00 |
Probable sodium-dependent transporter |
|
sll1450 |
2.89 |
3.98 |
5.27 |
Nitrate/nitrite transport system substrate-binding protein |
|
sll1451 |
2.52 |
1.73 |
5.97 |
Nitrate/nitrite transport system permease protein |
|
sll1452 |
1.98 |
1.66 |
3.12 |
Nitrate/nitrite transport system ATP-binding protein |
|
sll1481 |
3.14 |
1.66 |
3.38 |
ABC-transporter membrane fusion protein |
|
sll1482 |
3.30 |
1.51 |
2.57 |
ABC transporter permease protein |
|
sll1623 |
2.15 |
1.56 |
1.91 |
ABC transporter ATP-binding protein |
|
slr1248 |
2.57 |
2.63 |
3.00 |
Phosphate transport system permease protein PstC homolog |
|
slr1295 |
2.33 |
1.79 |
5.92 |
Iron transport system substrate-binding protein |
|
slr1318 |
1.50 |
2.50 |
1.77 |
Iron (III) dicitrate transport system ATP-binding protein |
|
slr1515 |
2.56 |
1.61 |
3.47 |
Putative membrane protein required for bicarbonate uptake |
|
slr1729 |
1.96 |
1.52 |
2.13 |
Potassium-transporting P-type ATPase B chain |
| slr2131 | 4.50 | 2.51 | 12.87 | RND multidrug efflux transporter |