Table 1. Pathoclinical features of GC and IHC score of RRM1.
| COH set (n = 67) | ZJU set (n = 322) | |||||
| No. of cases | RRM1-Higha N (%) | P value | No. of cases | RRM1-Higha N (%) | P value | |
| Age | ||||||
| <40 | 3 | 1 (33.3) | 19 | 10 (52.6) | ||
| 40–49 | 7 | 0 (0.00) | 48 | 18 (37.5) | ||
| 50–59 | 10 | 5 (50.0) | 89 | 36 (40.5) | ||
| 60–69 | 10 | 3 (30.0) | 83 | 43 (51.8) | ||
| 70–79 | 22 | 8 (36.4) | 76 | 42 (55.3) | ||
| >80 | 15 | 5 (33.3) | 0.22 | 7 | 5 (71.4) | 0.15 |
| Gender | ||||||
| Male | 44 | 17 (38.6) | 223 | 122 (54.7) | ||
| Female | 23 | 5 (21.7) | 0.15 | 99 | 32 (32.3) | <0.01 |
| Tumor Location b | ||||||
| Proximal | 30 | 16 (53.3) | 61 | 35 (57.4) | ||
| Body | 20 | 4 (20.0) | 73 | 32 (43.8) | ||
| Distal | 13 | 1 (7.7) | <0.01 | 169 | 79 (46.7) | 0.31 |
| Tumor Size (cm) | ||||||
| <5 cm | 34 | 10 (29.4) | 125 | 49 (39.2) | ||
| > = 5 cm | 32 | 11 (34.4) | 0.25 | 176 | 93 (52.8) | 0.02 |
| LN involvmentb | ||||||
| Negative | 17 | 4 (23.5) | 83 | 33 (39.7) | ||
| 1–2 | 13 | 3(23.1) | 45 | 15(33.3) | ||
| >2 | 36 | 14(38.9) | 0.40 | 180 | 92 (51.1) | <0.05 |
| Ki67 expression | ||||||
| Negative | 37 | 10 (27.0) | 101 | 33 (32.7) | ||
| Positve | 27 | 11 (40.7) | 0.25 | 192 | 108 (56.3) | <0.01 |
| Distant Metastasis | ||||||
| No | 60 | 19 (31.7) | 275 | 127 (46.2) | ||
| Yes | 6 | 2 (33.3) | 0.93 | 47 | 27 (57.5) | 0.15 |
| Histological types | ||||||
| Papillary | 7 | 4(57.1) | 21 | 13(61.9) | ||
| Tubular | 21 | 9(42.9) | 47 | 28(59.6) | ||
| Mucinos | 2 | 0(0.0) | 32 | 11(34.5) | ||
| Signet-ring | 16 | 4(25.0) | 49 | 7(14.29) | ||
| Undifferentiated | 19 | 5(26.3) | 0.41 | 167 | 92(55.1) | <0.01 |
| Histological grade | ||||||
| Low | 1 | 0 (0.00) | 24 | 17 (70.8) | ||
| Moderate | 19 | 9 (57.9) | 80 | 41 (51.3) | ||
| High | 47 | 12 (23.4) | 0.02 | 218 | 96 (44.0) | 0.03 |
NOTE: COH: City of Hope; and ZJU: Zhejiang University. All pathoclinical information was based on diagnosis at the time of first surgery. All cases with missing information were not included in statistical analysis.
a
High RRM1 includes positive and strong positive score in IHC staining.
b
Tumor location:(1) Proximal includes: Cardia, GEJ, Esophagus lower, fundus; (2) Body includes: lesser curve, greater curve, stomach overlapping, body; (3) Distal includes: Gastric antrum, pylorus.