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. 2013 Jul 19;14:74. doi: 10.1186/1471-2350-14-74

Figure 1.

Figure 1

The miR-663 promoter is methylated in AML cell lines. (A) Three CpG island regions can be identified in the promoter of miR-663. (B) MSP analysis of the methylation status of miR-663 in leukemia cell lines shows that the promoter is hypermethylated in 5/11 cell lines. M and U represent MSP results using primer sets for methylated and unmethylated miR-663 genes, respectively. (C) BGS results show the rate of CpG methylation is 91.3% in HL-60 cells, 86.2% in MV4-11 cells, and 81.9% in SHI-1 cells compared to 13.0% in CCRF cells, 21.0% in 697 cells, and 25.4% in Jurkat cells. ● methylated cytosines; ○ unmethylated cytosines.