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. 2013 Jul 21;10:51. doi: 10.1186/1743-7075-10-51

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Copyright © 2013 Ding et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Electron microscopic studies on pancreatic beta cells of normal and diabetic rats. Ultrastructural organization of pancreatic beta cells (A). Scale bar = 1 μm. ER: endoplasmic reticulum; MC: mitochondria; N: nucleus; SG: secretory granules. Mean density of SG was assessed by Image-Pro Plus 6.0 software and calculated as means ± SEM of 20 determinations in each group (B). See Figure 2 for groups and treatment. * P < 0.05 versus vehicle-treated normal rats, and # P < 0.05 versus vehicle-treated diabetic rats.