Figure 1.

(A–D) Feraspin R is endocytosed dose-dependently by 868 TCR-transduced CTLs, and adheres to the cell surface. 868 TCR-transduced CTLs were incubated for up to 24 hours with (A) 0 mg/mL, (B) 0.1 mg/mL (upper arrow shows internalized Feraspin R, lower arrow shows externally bound Feraspin R), (C) 0.5 mg/mL, and (D) 1 mg/mL Feraspin R.

Notes: Uptake was observed by transmission electron microscopy (magnification 20,000×). Cell-surface attachment (B) was detected. Scale bars are 500 nm.

Abbreviations: TCR, T-cell receptor; CTL, cytotoxic T lymphocyte.