Table 2.
Mean values of all variables by VDR genotype in subjects with MetSyn
|
Variables |
VDR 2228570 C > T (Fok I) |
p |
VDR 1544410 A > G (Bsm I) |
p |
||||
|---|---|---|---|---|---|---|---|---|
| |
FF |
Ff |
ff |
|
BB |
Bb |
bb |
|
| n = 130 | n = 91 | n = 22 | n = 109 | n = 102 | n = 32 | |||
| WC (cm) |
103 (±13) |
103 (±12) |
106 (±13) |
0.433 |
104 (±13) |
103 (±13) |
104 (±13) |
0.863 |
| Triglycerides (mg/dl) |
155 (±59) |
174 (±81) |
163 (±103) |
0.204 |
151 (±59) |
173 (±87) |
163 (±64) |
0.523 |
| BPS (mmHg) |
140 (±18) |
137 (±16) |
147 (±24) |
0.377 |
139 (±14) |
139 (±20) |
134 (±20) |
0.490 |
| BPD (mmHg) |
84 (±12) |
82 (±10) |
85 (±12) |
0.726 |
84 (±10) |
83 (±10) |
82 (±8) |
0.822 |
| Fasting glucose (mg/dl) |
99 (±10) |
98 (±13) |
99 (±14) |
0.707 |
100 (±12) |
97 (±13) |
99 (±12) |
0.404 |
| HDL cholesterol (mg/dl) |
43 (±12) |
40 (±9) |
40 (±12) |
0.306 |
43 (±12) |
42 (±10) |
40 (±12) |
0.231 |
| HOMA IR |
2 (±2) |
3 (±2) |
4 (±3)† |
0.014 |
3 (±1) |
3 (±2) |
4 (±3) |
0.259 |
| HOMA β |
100 (±77) |
159 (±137)‡ |
145 (±61) |
0.010 |
123 (±77) |
142 (±137) |
137 (±107) |
0.729 |
| 25(OH)D3 (ng/ml) |
24 (±6.8) |
24.8 (±16.8) |
24 (±8) |
0.828 |
24 (±6.4) |
62 (±8.4) |
24 (±8) |
0.389 |
| iPTH (pg/dl) | 37 (±19) | 49 (±22)‡ | 42 (±25) | 0.022 | 44 (±15) | 49 (±22) | 46 (±25) | 0.649 |
Legend:WC, Waist circumference; BPS, Systolic blood pressure; BPD, Diastolic blood pressure; HOMA IR, Insulin resistance; HOMA β, Cell function; iPTH, Intact parathyroid hormone; 25(OH)D3, Vitamin D. Data are expressed as mean (Standard Deviation). P values were calculated using ANOVA followed by Bonferroni test and adjusted for age. † significant for the heterozygous genotype; ‡ significant for the normal dominant homozygous genotype.