Table 3.
Mean values of all variables by VDR genotype in subjects without MetSyn
|
Variables |
VDR 2228570 C > T (Fok I) |
p |
VDR 1544410 A > G (Bsm I) |
p |
||||
|---|---|---|---|---|---|---|---|---|
| |
FF |
Ff |
ff |
|
BB |
Bb |
bb |
|
| n = 130 | n = 91 | n = 22 | n = 109 | n = 102 | n = 32 | |||
| WC (cm) |
89 (±10) |
95 (±16) |
90 (±9) |
0.086 |
93 (±14) |
93 (±13) |
86 (±11) |
0.293 |
| Triglycerides (mg/dl) |
90 (±28) |
117 (±54)‡ |
134 (±80) |
0.005 |
107 (±46) |
113 (±58) |
100 (±45) |
0.696 |
| BPS (mmHg) |
122 (±17) |
121 (±21) |
124 (±14) |
0.923 |
119 (±21) |
125 (±16) |
121 (±21) |
0.194 |
| BPD (mmHg) |
75 (±10) |
76 (±14) |
79 (±10) |
0.316 |
75 (±13) |
77 (±11) |
74 (±14) |
0.556 |
| Fasting glucose (mg/dl) |
92 (±10) |
92 (±11) |
89 (±10) |
0.607 |
92 (±11) |
90 (±9) |
93 (±8) |
0.588 |
| HDL cholesterol (mg/dl) |
50 (±11) |
45 (±12)‡ |
42 (±11) |
0.031 |
47 (±13) |
47 (±11) |
42 (±6) |
0.253 |
| Homa IR |
1.6 (±1.4) |
1.7 (±1.4) |
1.0 (±0.4) |
0.398 |
1.7 (±1.7) |
1.6 (±0.9) |
1.2 (±0.7) |
0.749 |
| Homa β |
92 (±62) |
103 (±80) |
87 (±93) |
0.711 |
96 (±81) |
107 (±71) |
70 (±46) |
0.424 |
| 25(OH)D3 (ng/ml) |
20 (±6) |
22 (±6.4) |
24.4 (±5) |
0.062 |
20.8 (±6) |
23 (±6.4) |
18 (±7.2)† |
0.023 |
| iPTH (pg/dl) | 41 (±24) | 36 (±18) | 38 (±11) | 0.019 | 40 (±20) | 37 (±20) | 32 (±24) | 0.361 |
Legend:WC, Waist circumference; BPS, Systolic blood pressure; BPD, Diastolic blood pressure; HOMA IR, Insulin resistance; HOMA β, Cell function; iPTH, Intact parathyroid hormone; 25(OH)D3, Vitamin D. Data are expressed as mean (Standard Deviation). P values were calculated using ANOVA followed by Bonferroni test and adjusted for age. † significant for the heterozygous genotype; ‡ significant for the normal dominant homozygous genotype.