Table 2.

Summary of studies included in the regions-of-interest group

				Demographic character										Methodological character
Study		ASD group		TD group													Value					ROI tract
	Na	Males	Mean age (years)	IQb	Nc	Males	Mean age (years)	IQb	Diagnostic tools	Medication / comorbidity	Tesla	B factor	Number of direction	NEX	TE/TR (ms)	Type of WBA	FA	MD	RD	AD	ADC	CC	UF	Cg	SLF	ILF	IFOF	Fo	AF
Whole brain voxel-wise analysis study
Alexander and colleagues [24]	43	43	16.2	107	34	34	16.4	113	DSM-IV/ICD-10/ADI-R/ADOS-G	Yes/Yes	3	1,000	12	4	84/7,000	ROI	○	○	○	○	×	○	×	×	×	×	×	×	×
Ameis and colleagues [43]	19	16	12.4	98.5	16	8	12.3	101	DSM-IV/ADI-R/ADOS	No/No	3	1,250	12	5	80/4,100	ROI	○	○	×	×	×	○	×	○	○	×	×	×	×
Beacher and colleagues [58]	28	15	32	NA	30	15	30	NA	DSM-IV	Yes/No	1.5	1,000	64	NA	95/8,000	ROI	○	×	×	×	×	○	×	×	×	×	×	×	×
Ben Bashat and colleagues [64]	17	NA	NA	NA	NA	NA	9.6	NA	DSM-IV/ADI-R/ADOS	NA/NA	1.5	6,000	6	4	128/1,800	ROI	○	○	×	×	×	○	×	○	○	×	×	×	×
Brito and colleagues [32]	8	8	9.53	NA	8	8	9.57	NA	DSM-IV	Yes/No	1.5	100	12	3	90/3,100		○	×	×	×	×	○	×	×	×	×	×	×	×
Catani and colleagues [67]	15	15	31	109	16	16	35	120	ICD-10/ADI/ADOS	NA/No	1.5	1,300	64	NA	107/1,500	Tractography	○	○	×	×	×	○	×	○	×	○	×	×	×
Cheon and colleagues [62]	17	17	11	112	17	17	10.2	114	DSM-IV/ ADI-R/ADOS	Yes/No	1.5	900	30	2	86/6500	ROI	○	○	×	×	×	×	×	×	×	×	×	×	×
Conturo and colleagues [74]	17	14	26.5	104	17	14	26.1	105	ADI-R/ADOS	Yes/No	1.5	NA	7	10	94/1,51750	Tractography	○	○	○	○	×	○	○	×	×	○	×	×	×
Fletcher and colleagues [59]	10	10	14.3	106	10	10	13.4	108	DSM-IV/ICD-10/ADI-R/ADOS	NA/NA	3	1,000	12	4	84/700	ROI	×	×	×	×	×	×	×	×	×	×	×	×	×
Hong and colleagues [60]	18	18	8.69	105	16	16	9.81	106	DSM-IV/ADI-R	No/No	1.5	1,000	15	2	104.4/8,000	ROI	○	×	×	×	○	○	×	×	×	×	×	×	×
Ingalhalikar and colleagues [69]	45	42	10.5	NA	30	14	10.3	NA	NA	NA/NA	3	1,000	15	NA	70/16,900	ROI	○	×	×	×	×	×	×	×	○	×	×	×	×
Knaus and colleagues [66]	14	14	16.1	103	20	20	14.1	116	DSM-IV/ADI-ADOS	NA/No	3	1,000	15	NA	N/A	Tractography	○	×	×	×	×	×	×	×	×	×	×	×	○
Kumar and colleagues [26]	32	29	5	NA	16	12	5.5	Na	DSM-IV	NA/No	3	1,000	6	6	79/10,000	Tractography	○	×	×	×	○	○	○	○	×	×	○	×	○
Langen and colleagues [73]	21	21	25.6	107	22	22	28.5	110	ICD-10/ADI-R/ADOS	No/No	3	1,300	32	NA	107/10,000	Tractography	○	○	○	○	×	×	×	×	×	×	×	×	×
Leemans and Jones [78]	43	43	16.2	108	34	34	16.4	113	DSM-IV/ICD-10/ADI-R/ADOS-G	NA/No	3	1,000	12	3	84/7,000	ROI	○	○	○	○	×	×	×	×	×	×	×	×	×
Lo and colleagues [25]	15	15	15.2	108	15	NA	15	111	DSM-IV/ICD-10/ADI-R	NA/No	3	6,000/4,000	102	NA	142/9,100, 130/9,600	ROI	○	×	×	×	×	○	○	○	×	×	×	×	○
Poustka and colleagues [63]	18	16	19.7	111	18	16	9.7	113	ICD-10/ADI/ADOS	NA/No	1.5	1,000	6	15	78/4,700	ROI	○	×	×	×	×	○	○	×	○	×	×	○	×
Pugliese and colleagues [57]	24	24	23.3	105	24	24	25.3	121	ICD-10/ADI-R	No/No	NA	1,300	32	NA	107/15,000	Tractography	○	○	×	×	×	×	○	○	×	○	○	○	×
Sahyoun and colleagues [71]	9	7	12.8	101	12	9	13.3	106	ADIM-IV/ADI-R	No/No	3	700	60	Na	84/7,980	ROI	○	×	×	×	×	×	×	×	×	×	×	×	×
Shukla and colleagues [65]	24	24	5	NA	16	12	5.9	NA	ADI-R/ADOS	Yes/No	3	200	15	4	99.4/1,0000	ROI		○	○	○	×	○	×	×	×	×	×	×	×
Sivaswamy and colleagues [68]	27	24	5	NA	16	12	5.9	NA	DSM-IV	Yes/No	3	1,000	6	6	160/11000	ROI	○	×	×	×	×	×	×	×	×	×	×	×	×
Sundaram and colleagues [72]	50	43	4.79	NA	16	11	6.84	NA	DSM-IV0	Yes/No	3	1,000	6	6	79/10,000	Tractography	○	×	×	×	○	×	×	×	×	×	×	×	×
Thomas and colleagues [28]	12	12	28.5	107	18	18	22.4	112	DSM-IV/ ADI-R/ADOS	NA/No	3	850	6	12	82/4,900	ROI	○	×	×	×	×	×	○	×	×	○	○	×	×
Verhoeven and colleagues [61]	19	16	13.8	NA	33	24	12.9	NA	DSM-IV	Yes/No	3	800	45	2	55/11,043	Tractography	○	×	×	×	○	×	×	×	○	×	×	×	×
Weinstein and colleagues [27]	22	NA	3.2	NA	28	NA	3.6	NA	DSM-IV ADI-R/ADOS	NA/Yes	1.5	1,000	15	2	94/11,043	Tractography	○	○	○	○	×	○	×	○	○	×	×	×	×

^aNumber of ASD participants. ^bMean IQ of participants. ^cNumber of controls. AD axial diffusivity, ADC apparent diffusion coefficient, ADIR Autism Diagnostic Interview-Revised, ADOS Autism Diagnostic Observation Schedule, AF arcuate fasciculus, ASD autism spectrum disorder, CC corpus callosum, Cg cingulum, DSM-IV Diagnostic and Statistical Manual of Mental Disorders-IV, FA fractional anisotropy, Fo fornix, ICD-10 International Statistical Classification of Diseases and Related Health Problems-10, IFOF inferior frontal occipital fasciculus, ILF inferior longitudinal fasciculus, MD mean diffusivity, NA not available, NEX number of excitation, RD radial diffusivity, ROI region of interest, SLF superior longitudinal fasciculus, TD typically developing, TE echo time, TR repetition time, UF uncinate fasculus.