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. 2013 Jul 29;8(7):e70113. doi: 10.1371/journal.pone.0070113

Table 3. The number and proportion of prescriptions with inappropriate splitting, by physician specialty.

Total Metabolism Cardiology Gen Med Neurology Psychiatry Nephrology Surgery Others
n (%) n (%) n (%) n (%) n (%) n (%) n (%) n (%) n (%)
All drug items 1238 (1.0) 429 (3.4) 297 (1.3) 149 (1.2) 88 (0.8) 86 (1.5) 81 (1.3) 47 (0.6) 61 (0.1)
Anti-diabetic Agents 623 (5.8) 347 (6.6) 111 (5.8) 81 (4.9) 10 (1.8) 0 37 (13.2) 7 (2.8) 30 (3.6)
Gliclazide MR tab30 mg (Diamicron®) 549 (6.7) 292 (7.2) 109 (6.7) 74 (6.4) 3 (0.9) 0 36 (14.4) 7 (4.7) 28 (4.7)
Metformin ER tab500 mg (Ansures®) 74 (2.9) 55 (4.8) 2 (0.7) 7 (1.4) 7 (2.9) 0 1 (3.3) 0 2 (0.9)
Cardiovascular Drugs 372 (0.7) 71 (1.1) 127 (0.7) 63 (1.0) 42 (1.0) 2 (0.5) 31 (0.9) 27 (1.4) 9 (0.1)
Fluvastatin XL tab80 mg (Lescol®) 224 (5.3) 45 (5.4) 81 (5.5) 50 (6.1) 16 (3.4) 0 17 (7.5) 15 (10.0) 0
Felodipine ER tab5 mg (Plendil®) 48 (0.4) 11 (0.7) 10 (0.2) 5 (0.2) 11 (0.7) 2 (0.9) 3 (0.3) 6 (1.1) 0
Doxazosin XL tab4 mg (Doxaben®) 27 (0.4) 8 (1.4) 9 (0.3) 3 (0.7) 3 (1.2) 0 2 (0.3) 0 2 (0.1)
Diltiazem retard tab90 mg (Cardizem®) 26 (0.7) 4 (1.0) 8 (0.3) 3 (1.9) 0 0 0 6 (4.8) 5 (4.4)
Nifedipine OROS tab30 mg (Adalat®) 18 (0.2) 0 6 (0.1) 0 0 6 (0.7) 0 6 (0.6) 0 0
Others 29 (0.2) 3 (0.3) 13 (0.4) 2 (0.1) 6 (0.6) 0 3 (0.6) 0 2 (0.0)
Central NervousSystem Agents 210 (0.9) 4 (4.0) 56 (11.4) 5 (1.0) 36 (0.8) 76 (1.7) 4 (10.3) 13 (0.4) 16 (0.2)
Alprazolam XR tab0.5 mg (Xanax®) 117 (6.5) 4 (5.3) 56 (13.4) 0 30 (8.0) 4 (2.2) 0 13 (9.9) 10 (2.0)
Bupropion XL tab150 mg (Wellbutrin®) 59 (3.6) 0 0 5 (11.1) 1 (1.3) 46 (3.2) 4 (80.0) 0 3 (14.3)
Valproate EC tab200 mg (Depakine®) 18 (0.9) 0 0 0 2 (0.3) 13 (1.1) 0 0 3 (1.6)
Others 16 (0.0) 0 0 0 3 (0.0) 13 (0.8) 0 0 0
Gastrointestinal Drugs 15 (0.1) 4 (0.7) 3 (0.3) 0 0 8 (1.0) 0 0 0
Others 18 (0.1) 3 (0.9) 0 0 0 0 9 (0.9) 0 2

Prescriptions for adult (age >18 yrs).

Metabolism, Metabolism & endocrinology; Gen Med, General medicine; n, number of prescriptions with inappropriate splitting.

%, n/N, proportion of prescriptions with inappropriate splitting by specific drug and physician specialty (N: number of prescriptions with special oral formulation by the specific drug and physician specialty in Table S1.).