Figure 3.

Notch-mediated nuclear transcription.

Abbreviations: NICD, Notch intracellular domain; CIR, CBF-interacting repressor; CSL, C promoter binding factor-1 [CBF-1], suppressor of hairless, Lag-1; HDAC, histone deacetylase; SMRT, silencing mediator of retinoid and thyroid hormone receptor; SHARP, SMRT/HDAC1 associated repressor protein; HAT, histone acetyltransferase; MAML, mastermind-like 1–3; SKIP, ski-interacting protein; Bcl-2, B-cell lymphoma 2; HES, hairy and enhancer of split; HEY, HES related with YRPW motif protein.