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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: Exp Eye Res. 2010 Jul 3;91(3):326–335. doi: 10.1016/j.exer.2010.06.021

Figure 5.

Figure 5

Healing in a corneal stromal incisional wound. The corneal epithelium loses it hemidesmosome attachment to the basement membrane and migrates over the wound site. The quiescent keratocytes are activated to proliferate and produce α smooth muscle actin but synthesize only low levels of ECM. The resulting hypercellular myofibroblasts accumulate in regions under the epithelium. The hypercellular myofibroblasts then become either wound fibroblasts that produce a normal collagen fibril containing ECM that restores transparency or become myofibroblasts that produce a light-scattering collagen fibril containing ECM that is opaque.