Table 1.

The effect of naringenin on the production of colonic TNF-α and IL-6 in dextran sulphate sodium (DSS)-induced colitis mice^‡

(Mean values and standard deviations of triplicates of two independent experiments)

	TNF-α (pg/mg protein)		IL-6 (pg/mg protein)
Group	Mean	sd	Mean	sd
Vehicle	20·8	1·9	34·8	3·7
Naringenin	27·7	2·5	41·1	2·6
DSS+vehicle	184·3†	16·1	244·7†	13·8
DSS+naringenin	79·4***	6·8	112·9**	11·4

Mean values were significantly different compared with the DSS-treated group:

^**P<0·01,

^***P<0·001.

^†Mean values were significantly different compared with the vehicle-treated group (P<0·001).

^‡Segments of mid-colon samples from mice (n 6 per group) were excised and homogenised. The supernatants were assayed for the determination of the levels of TNF-α and IL-6 using the ELISA method (R&D Systems).