Comparison of liver injury and inflammation induced by chronic, binge and chronic-binge feeding. C57BL6/J mice were subjected to chronic, binge or chronic-binge feeding. (A) Liver injury was assessed by measuring serum ALT and AST levels. (B, C) Liver mRNA levels of cytokines (B) and chemokines (C) were analyzed by real-time PCR. *P<0.05, **P<0.01, ***P<0.001.