Figure 3. Inhibition of I _KAS with amiodarone is dose-dependent.

(A) I _KAS was induced by the ramp pulse protocol used in Figure 2. (B) Time-course of I _K measured at 0 mV in the absence and presence of various amiodarone concentrations and apamin. The dotted line indicates the level of baseline I _K. (C) Dose-dependent inhibitory effects of amiodarone on I _KAS. The numbers in parenthesis indicate number of patches. The error bars represent S.E.