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. 2013 Jul 29;8(7):e70346. doi: 10.1371/journal.pone.0070346

Table 5. Univariate and multivariate hazards ratios for overall survival in 248 patients with metastatic non-small cell lung cancer.

Univariate Multivariate
Variables HR 95% CI P HR 95% CI P
Histology
Adeno 1 1
Squamous 1.2 0.7–2.1 0.41 1.2 0.7–2.1 0.48
Large Cell 1.8 1.2–2.8 <0.01 2.2 1.4–3.4 <0.01
Mutation result
EGFR/ KRAS WT 1 1
EGFR mutation 0.4 0.2–0.7 <0.01 0.3 0.1–0.6 <0.01
KRAS mutation 1.1 0.7–1.5 0.70 1.1 0.8–1.8 0.34
No test performed 1.2 0.8–1.9 0.33 1.4 0.8–2.1 0.31
Metastasis *
Spinal bone 1.5 1.0–2.2 0.05 1.7 1.2–2.6 <0.01
Brain 0.9 0.6–1.4 0.67
Lung 1.1 0.8–1.5 0.64

HR>1 means a shorter survival.

*

denotes presence of metastasis at specific site.