Figure 8. CYP-induced bladder overactivity is decreased in Trpc1/c4^−/− mice.

A, Typical urodynamic traces of WT and Trpc1/c4^−/− mice in vehicle or following CYP treatment. B,C, Analysis of intercontractile interval in vehicle (B) and CYP-treatment mice (C) in WT and Trpc1/c4^−/− mice shows that double knock-out mice are functionally less affected by CYP treatment. D, Typical muscle strip contractility traces of WT mice in control and in CYP_c rats activated by 10 nM of carbachol. The statistical analysis of carbachol-induced contraction of muscle strips did not show difference between the two genotypes in CYP_c mice. E, Typical traces of muscle strip contractility of WT mice stimulated with high KCl concentration (122 mM). There is no difference between WT and Trpc1/c4^−/− in control and CYP_c conditions.