Table 2. The effect of synthetic Agonists on the Ms5HT1A and Ms5HT1B receptors.
| Drug | Receptor Subtype Specificity | 5HT1A receptor | n | 5HT1B receptor | n |
|---|---|---|---|---|---|
| 5HT | Non-specific | 100% (158.3 ± 17.4 nA) | 23 | 100% (100.5 ± 17.6 nA) | 30 |
| 5-Methoxytryptamine | Non-specific | 20.8 ± 6.7% | 5 | 7.2 ± 1.4% | 7 |
| 2-Methyl-5-hydroxy-tryptamine | Non-specific | 3.9 ± 2.2% | 3 | 0 | 4 |
| 8-Hydroxy DPAT | Non-specific | 0 | 4 | 0 | 3 |
| 5-Carboxamido-tryptamine | Non-specific | 0 | 3 | 0 | 3 |
| 8-Hydroxy-PIPAT | 5HT1A | 0 | 3 | 0 | 4 |
| BP554 | 5HT1A | 0 | 3 | 0 | 4 |
| 5-Nonyloxy-tryptamine | 5HT1B | 0 | 3 | 0 | 7 |
| CP94253 | 5HT1B | 0 | 3 | 0 | 4 |
| AS19 | 5HT7 | 0 | 3 | 0 | 3 |
| LP44 | 5HT7 | 0 | 3 | 0 | 3 |
The 5HT1A responses were measured in oocytes coinjected with receptor cRNA and cRNA for the CFTR channel while the 5HT1B responses were measured in oocytes injected with the receptor cRNA alone. Oocytes were exposed to 2 min pulses of the agonists at a concentration of 1 µM. Results are expressed as a percentage ± SEM of the response of the same oocytes to 2 min control pulses of 5HT.