Table 4. Four SNPs from the meta-analysis of 66 SNPs using GAIN, nonGAIN, and ISC GWAS datasets.
Gene | SNP ID | Chr. | Position (bp) | Allele | Meta-analysis | ||||||||
p-value | Beta | s.e. | pheterogeneity | I2 | pGAIN | pnonGAIN | pISC | IHDS min p | |||||
PRKCE | rs2176348 | 2 | 45798033 | A/G | 0.044 | −0.064 | 0.032 | 0.838 | 0 | 0.470 | 0.599 | 0.057 | 0.004 |
MGMT | rs552551 | 10 | 131271915 | C/T | 0.044 | 0.073 | 0.036 | 0.29 | 19.15 | 0.996 | 0.797 | 0.011 | 0.009 |
CNTN4 | rs2616591 | 3 | 2614861 | C/T | 0.048 | 0.088 | 0.044 | 0.481 | 0 | 0.347 | 0.061 | NA | 0.004 |
NPAS2 | rs2043534 | 2 | 100847317 | C/T | 0.062 | 0.064 | 0.035 | 0.635 | 0 | 0.258 | 0.808 | 0.081 | 0.003 |
Chr.: chromosome. GAIN, nonGAIN and ISC are three GWAS datasets for meta-analysis. ISHDSF min p was the smallest p-value in the gene from the IHDS dataset (this study). NA: this SNP was not analyzed in ISC due to missing genotyping data in samples.