Table 1.
Prospective studies evaluating the effect of occult B infection (OBI) or potential OBI on carcinogenesis in patients with chronic hepatitis C.
| Author | Country | Year | Study design | No. of patients | No. of HCC occurrence / OBI or potential OBI positive patients (%) | No. of HCC occurrence / OBI or potential OBI negative patients (%) |
|---|---|---|---|---|---|---|
| Hasegawa, et al18 | Japan | 2005 | Prospective | 140 | 2 / 11 (18.2%) | 16 / 129 (12.4%)** |
| Squadrito, et al39 | Italy | 2006 | Prospective | 124 | 8 / 50 (16.0%) | 1 / 74 (1.4%) * |
| Ikeda, et al16 | Japan | 2007 | Prospective | 846 | 130 / 392 (33.2%) | 107 / 454 (23.6%) * |
| Matsuoka, et al32 | Japan | 2008 | Prospective | 468 | 29 / 204 (14.2%) | 9 / 264 (3.4%) * |
| Obika, et al45 | Japan | 2008 | Prospective | 167 | 2 / 25 (8.0%) | 10 / 142 (7.0%) ** |
| Anna, et al46 | USA | 2011 | Prospective | 273 | 38 / 121 (31.4%) | 53 / 152 (34.9%) ** |
HCC; hepatocelluar carcinoma, *; statistically significant, **; statistically not significant