Fig 4.

ICG-001 modulates WNT/catenin activity and apoptosis in p300 deficient HCT-15 CRC cells. (A) Western blot data confirming expression of CBP and lack of p300 expression in HCT-15 cells, mock treated (M) or treated with 5 mM butyrate (B). (B) ICG-001 inhibits butyrate-induced WNT activity in HCT-15 cells. Experiments were performed as in Fig 3B. Data are from three separate experiments. (C) Butyrate and ICG-001 influence apoptosis in HCT-15 cells. Experiment performed as in Fig. 3C. Data are from three separate experiments. Bars, SDs. * = statistical significance.