Table 2.
Univariate analysis of factors contributing to overall survival (OS) and recurrence-free survival (RFS) after surgical resection for all cases (n=475).
| OS | RFS | ||
|---|---|---|---|
| Variables | n | P-valuea | P-valuea |
| Age ≥70 years (yes/no) | 223/252 | 0.153 | 0.867 |
| Gender (male/female) | 340/135 | 0.452 | 0.317 |
| Cause of liver disease | |||
| Hepatitis B/hepatitis C/nonB nonC | 62/284/129 | 0.088 | 0.557 |
| HCC stage (I, II / III, IV) | 314/161 | <0.001 | <0.001 |
| Maximum tumor size ≥4 cm (yes/no) | 229/246 | 0.001 | 0.025 |
| Tumor number (single/multiple) | 314/161 | <0.001 | <0.001 |
| Presence of LC (yes/no) | 262/213 | <0.001 | <0.001 |
| Total bilirubin ≥ 0.8 mg/dl (yes/no) | 236/239 | 0.208 | 0.995 |
| Serum albumin ≥3.9 g/dl (yes/no) | 255/220 | <0.001 | 0.044 |
| AST ≥50 IU/l (yes/no) | 214/261 | 0.137 | 0.095 |
| ALT ≥50 IU/l (yes/no) | 182/293 | 0.389 | 0.097 |
| ALP ≥ 300 IU/l (yes/no) | 237/238 | 0.013 | 0.001 |
| GGT ≥80 IU/l (yes/no) | 207/268 | 0.026 | <0.001 |
| Platelets ≥13×104/mm3 (yes/no) | 249/226 | 0.228 | 0.078 |
| Prothrombin time ≥88 % (yes/no) | 259/216 | 0.006 | 0.033 |
| Diabetes mellitus (yes/no) | 149/325 | 0.307 | 0.982 |
| Body mass index ≥23 kg/m2 (yes/no) | 222/253 | 0.542 | 0.022 |
| AFP ≥20 ng/ml (yes/no) | 237/238 | <0.001 | <0.001 |
| DCP ≥200 mAU/ml (yes/no) | 240/235 | 0.003 | 0.005 |
| Microscopic vascular invasion (yes/no) | 172/303 | <0.001 | <0.001 |
| Microscopic surgical margin (yes/no) | 123/352 | 0.405 | 0.685 |
HCC; hepatocellular carcinoma, LC; liver cirrhosis, AST; aspartate aminotransferase, ALT; alanine aminotransferase, ALP; alkaline phosphatase, GGT; gamma glutamyl transpeptidase, AFP; alpha-fetoprotein, DCP; des-γ-carboxy prothrombin, a; Log-rank test.