Table 5.
Univariate and multivariate analysis of factors contributing to overall survival (OS) and recurrence-free survival (RFS) after surgical resection in patients without liver cirrhosis (n=213).
| OS | Multivariate analysis (OS) | RFS | Multivariate analysis (RFS) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Variables | n | P-valuea | HR | 95%CI | P-valueb | P-valuea | HR | 95%CI | P-valueb |
| Age ≥70 years (yes/no) | 106/107 | 0.527 | 0.939 | ||||||
| Gender (male/female) | 170/43 | 0.548 | 0.091 | 0.650 | 0.397-1.065 | 0.087 | |||
| Cause of liver disease | |||||||||
| Hepatitis B/hepatitis C/nonB nonC | 27/103/83 | 0.963 | 0.733 | ||||||
| HCC stage (I, II/III, IV) | 139/74 | 0.001 | 0.360 | 0.116-1.118 | 0.077 | <0.001 | 0.560 | 0.263-1.194 | 0.133 |
| Maximum tumor size ≥4 cm (yes/no) | 125/88 | 0.001 | 0.477 | 0.264-0.864 | 0.015 | 0.002 | 0.643 | 0.413-1.000 | 0.050 |
| Tumor number (single/multiple) | 146/67 | 0.008 | 1.616 | 0.522-5.006 | 0.405 | <0.001 | 0.979 | 0.462-2.074 | 0.955 |
| Total bilirubin ≥0.8 mg/dl (yes/no) | 77/136 | 0.604 | 0.578 | ||||||
| Serum albumin ≥3.9 g/dl (yes/no) | 155/58 | 0.112 | 0.161 | ||||||
| AST ≥50 IU/l (yes/no) | 105/108 | 0.552 | 0.096 | 1.373 | 0.850-2.216 | 0.195 | |||
| ALT ≥50 IU/l (yes/no) | 94/119 | 0.132 | 0.060 | 0.940 | 0.562-1.572 | 0.813 | |||
| ALP ≥300 IU/l (yes/no) | 79/134 | 0.644 | 0.002 | 0.718 | 0.489-1.053 | 0.090 | |||
| GGT ≥80 IU/l (yes/no) | 99/114 | 0.038 | 0.651 | 0.403-1.053 | 0.080 | <0.001 | 0.642 | 0.435-0.949 | 0.026 |
| Platelets ≥13×104/mm3 (yes/no) | 178/35 | 0.543 | 0.558 | ||||||
| Prothrombin time ≥88 % (yes/no) | 154/59 | 0.444 | 0.115 | ||||||
| Diabetes mellitus (yes/no) | 69/143 | 0.903 | 0.382 | ||||||
| Body mass index ≥23 kg/m2 (yes/no) | 96/117 | 0.981 | 0.210 | ||||||
| AFP ≥20 ng/ml (yes/no) | 82/131 | 0.028 | 0.694 | 0.424-1.135 | 0.146 | 0.044 | 0.753 | 0.514-1.103 | 0.146 |
| DCP ≥200 mAU/ml (yes/no) | 124/89 | 0.011 | 0.977 | 0.518-1.842 | 0.943 | 0.010 | 1.159 | 0.723-1.859 | 0.539 |
| Microscopic vascular invasion (yes/no) | 74/139 | 0.015 | 0.814 | 0.469-1.413 | 0.464 | 0.004 | 0.740 | 0.489-1.122 | 0.156 |
| Microscopic surgical margin (yes/no) | 52/161 | 0.547 | 0.129 | ||||||
HR; hazard ratio, CI; confidence interval, HCC; hepatocellular carcinoma, AST; aspartate aminotransferase, ALT; alanine aminotransferase, ALP; alkaline phosphatase, GGT; gamma glutamyl transpeptidase, AFP; alpha-fetoprotein, DCP; des-γ-carboxy prothrombin, a; Log-rank test, b; Cox proportional hazard model.