Figure 6. Biliverdin Treatment Increases Hepatocyte Proliferation After IRI.

A. Representative immunostaining images for Ki-67 as a marker of cell proliferation in liver sections harvested pre-ischemia, immediately post-ischemia and 12 hrs after reperfusion ± BV treatment. Effects of biliverdin on Ki-67 expression as an indicator of cell (primarily hepatocyte) proliferation. B. Ki-67 positive cells were counted and expressed as a percentage of positive cells among the total number of cells present in each field. Data are expressed as mean ± SD of n = 3 pigs/group where a total number of cells counted was at least 500. Magnification = 400×, Bar represents 50 µm. (*p = 0.046).