Fig. 1.
Experimental protocols used to determine myocardial infarct size in C57BL/6J mice (A); O2·− formation, endothelial nitric oxide (NO) synthase (eNOS) dimerization, and eNOS, phosphorylated (p-)eNOS, and caveolin (Cav)-1 compartmentalization in human coronary artery endothelial cells (HCAECs; B), and NO production in HCAECs (C). AHG, acute hyperglycemia; APC, anesthetic preconditioning; BFA, brefeldin A; CON, control; D-4F, Ac-DWFKAFYDKVAEKFKEAF-NH2 (apolipoprotein A-1 mimetic); l-NAME, NG-nitro-l-arginine methyl ester (NO synthase inhibitor); OCC, occlusion.