Table 2.

Aggressive cases of BIA-ALCL

Case/Ref.	Age/Int. at ALCL, PMH	Textured BI filled with	Presentation/Sites of disease	Markers	Genetics/ALK Status	Treatment/Outcome
Alobeid et al. 2009	68/16, history of Rt breast ductal CA and PBC	silicone	Rt axillary LAD/Rt axillary LNs, Rt BI capsule, Lt axillary LNs	CD30+, CD45-/+, CD15+, CD2+, CD4+, EMA+, MUM1+	complex ALK-	CPT, 6 cycles CHOP/No known relapse
Carty et al. 2011	57/32, multiple BI revisions due to capsular contraction and implant rupture	silicone	B-symptoms, Lt axillary LAD/Lt BI capsule with chest wall invasion and pleural thickening	CD30+, CD4+	Complex ALK-	CPT, RT, 5 cycles CHOP, salvage CT, ASCT/Death from progressive disease 3 years after diagnosis
Gaudet et al. 2002	50/10, Lt breast CA, remote history of HL	Silicone	Mass overlying Rt BI/Dermal involvement overlying Rt BI	CD30+, CD2+, LCA+, weakly positive for CD3, CD5, CD43	Complex ALK-	CHOP/Relapse 1 year later with pleural and pericardial effusions, mediastinal LAD; Unknown current status
Aladily et al. 2012	63/6+1, L breast CA, 3 yr history of lyP	saline	Effusion & mass in Rt breast/Rt breast	CD30+, CD3+, CD4+, CD2+, CD43+	Complex ALK-	CPT/Died at 12 yrs post ALCL diagnosis
Aladily et al.	47/9, breast CA	saline	Rt BI mass/Rt breast with effusion	CD30+, CD45+, CD43+, CD4+, EMA+, Granzyme B	Complex ALK1-	CPT, RT, CT/Died at 2 yrs post ALCL diagnosis
Our Case	67/8, breast CA	Silicone	Enlargement and Effusion in Rt breast/Rt breast	CD30+, CD15+, CD25+, CD8+,	Complex with genetic evolution ALK-	CPT at diagnosis, CHOP/ Etoposide at relapse. Patient is well without detectable disease

Int., interval; Rt, right; Lt, left; BI, breast implant; CA, carcinoma; LN, lymph node; LAD, lymphadenopathy; LyP, lymphomatoid papulosis; CPT, capsulectomy; RT, radiation therapy; CT, chemotherapy; ASCT, autologous stem cell transplantation; CHOP, PBC, primary billiary cirrhosis; ALK-, anaplastic lymphoma kinase gene rearrangement negative; Ref., reference.