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. 2013 Jul 15;6(8):1643–1651.

Figure 2.

Figure 2

Microscopic features of the dural lymphoma. A: At low power field, the lymphoma is located in the dura matter composed of a thick, dense, fibrous connective tissue (hematoxylin and eosin stain, x 40). B: The lymphoma is composed predominantly of CD3-positive cells (CD3, x 40). C: CD20, the most widely used pan B-cell marker, is negative (CD20, x 40). D: At high power field, the lymphoma is composed of large anaplastic cells admixed with lymphocytes and histiocytes. The malignant cells have eccentric bizarre nuclei with prominent nucleoli (red arrow). Multinucleated cells resembling RS cell are seen (red arrow head) (hematoxylin and eosin stain, x 400). E: All malignant cells show strong membranous and cytoplasmic staining for CD3 (CD3, x 400). F: The malignant cells show membranous, cytoplasmic and paranuclear dot-like staining for CD30 (CD30, x 400). G: Anaplastic large cells show cytoplasmic and nuclear staining for ALK (ALK, x 400). H: The staining pattern for epithelial membrane antigen is similar to that seen with CD30 (EMA, x 400). I: Malignant cells are negative for CD15 (CD15, x 400).