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Histopathological features of the bone marrow of the first biopsy specimen. A: Fat cell atrophy, deposition of extracellular gelatinous materials, and decrease in the trilineage hematopoietic cells are observed. HE, x 200. B: The extracellular gelatinous materials are positive for Alcian blue staining. Alcian blue staining, x 200. C: The extracellular gelatinous materials are digested by hyaluronidase. Alcian blue staining with digestion by hyaluronidase, x 200.
