Figure 2.
Inclusion bodies, iron deposits, and immunohistochemistry from a patient with hereditary ferritinopathy. Sections of putamen show numerous ferritin IBs of various sizes (A–E), which are ubiquitinated (E). Ferritin IBs were also present in neurons and glial cells of the cerebellum (F). Hematoxylin and eosin (A); Perls' Prusian blue method for iron (B); and immunohistochemistry using antibodies against mutant FTL (C), wild-type FTL (D), ubiquitin (E), and FTH1 (F). Scale bars: (A–F), 50 μm.