Figure 5.
Inclusion bodies and immunohistochemistry from a transgenic mouse model of hereditary ferritinopathy. Sections of cerebral cortex (A), globus pallidus (B), and cerebellum (C) of FTL-Tg mice show the presence of numerous ferritin IBs. Sections were from a 9 month old homozygous male (A,B) and an 11 month old heterozygous male (C). Immunohistochemistry was performed using antibodies against the N-terminus of wild-type and mutant FTL (A–C). Scale bars: (A–C), 50 μm.