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Dose-dependent effect of LY341495 on tibial inhibition of bladder overactivity induced by 0.25% AA. CMG at each dose of LY341495 was performed in sequence from left to right in A–C. A: AA CMG without stimulation. B: AA CMG during 2T stimulation. C: AA CMG during 4T stimulation. Black bars under pressure trace indicate stimulation duration. Stimulation: 5 Hz, 0.2 ms, intensity threshold T = 0.7 V. Arrows indicate start and stop of bladder infusion. Infusion rate = 1 ml/min.
