Fig. 5.

LY341495 pretreatment significantly reduces the naloxone dosage required to eliminate TNS inhibition of bladder overactivity induced by 0.25% AA infusion. A: naloxone effect in LY341495 (5 mg/kg) pretreated animals (n = 9 cats). B: naloxone effect without LY341495 pretreatment (n = 8 cats). Bladder capacities were normalized to the capacity measured during AA control CMG before naloxone treatment (i.e., at 0 mg/kg naloxone). Stimulation: 5 Hz, 0.2 ms, T = 0.35–2.4 V. *Significantly different from control capacity at each dosage (two-way ANOVA).