Fig. 2.
Effects of CGS-21680 on EEG delta power and non-REM and REM latencies. Effects of vehicle and CGS-21680 after intracerebroventricular (8 nmol or 24 nmol) and SS-rBF (8 nmol) microinjection on non-REM delta power (A), non-REM sleep latency (B), and REM sleep latency (C). Both intracerebroventriclar (ICV) and SS-rBF injections of CGS-21680 increased non-REM delta power (ICV: F2,18 = 3.555; P = 0.05; SS-rBF: t = −2.39; P = 0.034) and decreased latencies for both non-REM sleep (ICV: F2,18 = 7.14; P = 0.005; SS-rBF: t = 3.90; P = 0.002) and REM sleep (ICV: F2,18 = 3.24; P = 0.063; SS-rBF: t = 2.82; P = 0.015). The non-REM sleep delta power is expressed as the % change from baseline waking values. *Significantly different from vehicle, P < 0.05.