Fig. 4.

Kinetic analysis of the rise and decay time course for spontaneous EPSCs (singles). A and B: rise time (A) and decay τ (B) plotted against peak current for individual EPSCs showing a great deal of scatter, with both currents and rise times varying 4-fold. A line could be fit to the envelope of the response indicating a trend for larger EPSCs to be slower than smaller (see red and blue lines, respectively). C: examples of EPSCs of similar sizes but different kinetic behavior for both large and small EPSCs. Blue traces show differences in the decay times, while red shows differences in rise time. D: a similar plot where small and large EPSCs were scaled to show that the kinetics were similar. E and F: envelope fits for individual cells for both rise (E) and decay (F) times. Each cell similarly showed the trends for slowing with larger current amplitudes. G: the rise time for a given cell plotted against its decay time to demonstrate that no clear relationship exists (fast rise times are observed with slow decay and vice versa). Red line indicates a fit with r² = 0.02.