Table 2.
99mTc-PYP SPECT data according to amyloid subtype
| Category | AL n=12 | ATTRwt n=16 | ATTRm n=17 | P value |
|---|---|---|---|---|
| Semi-quantitative Visual Cardiac Score (%) | ||||
| Score <2 | 83 | 0 | 6 | <0.0001 |
| Score ≥2 | 17 | 100 | 94 | |
| Quantitative Cardiac Score (cts) | ||||
| Heart absolute cts | 21.8±2.7 | 27.7±0.9 | 30.4±3.6 | 0.10 |
| CL absolute cts | 18.1±2.2 | 15.3±0.6 | 17.5±2.4 | 0.48 |
| H/CL ratio | 1.21±0.04 | 1.84±0.06a | 1.77±0.06a | <0.0001 |
| Heart SD mean cts | 5.4±0.3 | 6.5±0.2 | 6.7±0.5a | 0.033 |
| CL SD mean cts | 4.4±0.3 | 4.6±0.1 | 4.7±0.4 | 0.73 |
| Heart mean max cts/pix | 40.2±3.7 | 52.0±1.8 | 54.2±4.8a | 0.041 |
| CL mean max cts/pix | 35.3±3.1 | 34.6±0.8 | 35.5±3.2 | 0.88 |
| Heart mean total cts/ROI | 38,966±4,528 | 60,709±4,423a | 58,346±4,764a | 0.008 |
| CL mean total cts/ROI | 32,132±3,591 | 33,904±1,724 | 35,285±3,140 | 0.72 |
| Heart mean area ROI (mm2) | 4,672±417 | 5,356±302 | 5,303±336 | 0.36 |
| CL mean area ROI (mm2) | 4,619±412 | 5,295±298 | 5,262±342 | 0.36 |
Continuous data are expressed as mean± SE, and categorical data are expressed as percentages.
Semi-quantitative and quantitative data were obtained 1 hour post 99mTc-PYP infusion.
Cts indicates counts; CL, contralateral; SD, standard deviation; Pix, pixels; ROI, region of interest.
P<0.05 by ANOVA with Bonferroni correction in comparison to AL.