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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 Nov 27;39(6):683–710. doi: 10.1007/s10928-012-9279-8

Fig. 3.

Fig. 3

Comparison of PBPK model-predicted and observed T84.66 population mean AUCs in LS174T xenograft-bearing SCID mice. Black bars represent the predicted T84.66 AUC0–10 days in plasma, LS174T tumors, and other tissues. Error bars represent the standard deviation around the mean (n = 1,000 subjects). Gray Bars represent the observed mean T84.66 AUC0–10 days in plasma, tumor and other tissues. Sub groups of three mice were sacrificed at several time points (t = 1 h–10 days), AUCs were calculated using NCA for sparse sampling module (WinNonlin 6.1). Error bars represent the standard deviations around the mean calculated using a modified Bailer method