Table 1.

PBPK model parameters

Description	Parameter	Unit	Mean (SD)	References
CEA concentration in LS174T xenografts or cell lines	[CEA] (LS174T)	M	1.52 × 10−6 (1.53 × 10−6)	[17, 21, 33, 35, 36]
CEA concentration in HT29 xenografts or cell lines	[CEA] (HT29)	M	1.59 × 10 − 7 (1.7 × 10 − 7)	[32, 33, 35, 37, 38]
mAb-CEA internalization rate constant	kint	min−1	8.75 × 10−4 (2.45 × 10−4)	[11, 17]
mT84.66-CEA binding equilibrium dissociation constant	$\left(K_{d\text{tumor}}^{\mathit{CEA}}\right)$	M	2.33 × 10−11 (1.27 × 10−11)	[39, 40]
Tumor vasculature reflection coefficient (sigma)	${\sigma }_{\text{tumor}}^{\nu }$	–	0.734 (0.189)	[20, 23, 44]