Table 2.
Summary parameters for plasma pharmacokinetics of T84.66 and 8C2
| Group | Dose (mg/ kg) |
CLp (ml/ day/ kg) |
Vss (ml/ kg) |
AUC0–10 days (nM × day) |
|---|---|---|---|---|
| T84.66_Control | 1 | 6.2 | 211 | 2.95 × 102 ± 11.8 |
| 10 | 5.5 | 127 | 4.54 × 103 ± 2.0 × 102 | |
| 25 | 6.5 | 140 | 9.51 × 103 ± 2.9 × 102 | |
| T84.66_LS174T | 1 | 79.3 | 93 | 84 ± 3.04 |
| 10 | 21.9 | 135 | 2.37 × 103 ± 1.54 × 102 | |
| 25 | 23.2 | 125 | 5.96 × 103 ± 3.17 × 102 | |
| 8C2-LS174T | 1 | 19.7 | 264 | 1.82 × 102 ± 7.55 |
| 25 | 10.6 | 188 | 7.84 × 103 ± 24.3 | |
| T84.66-HT29 | 0.025 | 220 | 376 | 0.752 ± 0.123 |
| 0.1 | 130 | 388 | 4.81 ± 0.74 | |
| 1 | 16.1 | 193 | 2.34 × 102 ± 2.09 × 101 | |
| 10 | 15.8 | 117 | 3.15 × 103 ± 1.81 × 102 | |
| 25 | 12.0 | 149 | 7.51 × 103 ± 6.26 × 102 |
T84.66_Control refers to data collected from control, non-tumor bearing mice that were administered T84.66. T84.66_LS174T refers to data collected from SCID mice bearing LS174T xenograft tumors. 8C2_LS174T refers to 8C2 data collected from SCID mice bearing LS174T xenograft tumors. T84.66_HT29 refers to T84.66 data collected from SCID mice bearing HT29 xenograft tumors. T84.66 pharmacokinetics show clear dose dependencies, thus violating a major assumption for the use of moment analysis to determine disposition parameters. As such, estimates of CL and Vss should be viewed with caution