. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 Nov 27;39(6):683–710. doi: 10.1007/s10928-012-9279-8

Table 4.

Comparison of PBPK model predicted mean apparent clearance versus observed apparent clearance in SCID mice

Group	Dose (mg/kg)	CL_p (predicted) ml/day/kg	CL_p(Observed) ml/day/kg
T84.66_LS174T	1	61.8	79.3
	10	32.1	21.9
	25	22.9	23.2
8C2-LS174T	1	10.7	19.7
	25	11.7	10.6
T84.66-HT29	0.025	65.1	220
	0.1	55.6	130
	1	26.4	16.1
	10	12.4	15.8
	25	11.1	12.0

T84.66_LS174T refers to T84.66 data collected from SCID mice bearing LS174T xenograft tumors. 8C2_LS174T refers to 8C2 data collected from SCID mice bearing LS174T xenograft tumors. T84.66_HT29 refers to T84.66 data collected from SCID mice bearing HT29 xenograft tumors