Table 5.

Parameter symbols and definitions

Parameter	Unit	Definition
Qorgan	ml/min	Plasma flow rate to organ
Lorgan	ml/min	Lymph flow rate to organ
Vp	ml	Volume of plasma compartment
$V_{\text{organ}}^{\nu }$	ml	Volume of organ vascular space
$V_{\text{organ}}^E$	ml	Volume of organ endosomal space
$V_{\text{organ}}^{\mathit{IS}}$	ml	Volume of vascular space
Cplasma	M	Antibody concentration in plasma
Cplasma(0)	M	Antibody concentration in plasma at time zero
$C_{\text{organ}}^V$	M	Antibody concentration in each organ vascular space
$C_{\text{organ}}^E$	M	Antibody concentration in each organ endosomal space
$C_{\text{organ}}^{\mathit{IS}}$	M	Antibody concentration in each organ interstitial space
CLorgan	ml/min	Antibody clearance from each organ
K0	M/min	Endogenous IgG production rate
nptorgan	M	FcRn concentration in each organ
$K_d^{\mathit{FcRn}}$	M	Antibody-FcRn equilibrium dissociation constant
fuorgan		Fraction of antibody unbound to FcRn
${\mathit{fu}}_{\text{tumor}}^{\mathit{IS},\text{cell}}$		Fraction of antibody unbound to tumor antigen in the interstitial space
FR		Fraction of antibody recycled upon binding to FcRn
R1	min−1	Endosomal uptake and recycling rate of antibody
${\sigma }_{\text{organ}}^V$		Vascular reflection coefficient of each organ
${\sigma }_{\text{organ}}^L$		Lymph reflection coefficient of each organ
Tau	min	Transit time for lymph transfer from lymph node to plasma
Xlymph	mol	Amount of antibody in lymph compartment
$V_{\text{tumor}}^{\text{Cellular}}$	ml	Volume of tumor cellular sub-compartment
$K_{d\text{tumor}}^{\mathit{CEA}}$	M	Antibody-CEA equilibrium dissociation constant
kint	min−1	Antibody-CEA internalization rate constant
FA		Fraction of antigen available for antibody binding
nPtorgan	M	Tumor antigen concentration in the tumor cellular space