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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 Nov 27;39(6):683–710. doi: 10.1007/s10928-012-9279-8

Table 6.

Organ-specific parameter values

Organ Total volume (ml) Vascular volume (ml) Interstitial
volume (ml)		 Endosomal
volume (ml)		 Plasma flow
(ml/min)		 Organ clearance
(ml/min)
Plasma 0.774
Lung 0.191 0.0191 0.057 9.55 × 10−4 1.43 × 10−6
GI 3.45 0.1 0.6 1.73 × 10−2 0.9 2.58 × 10−5
Liver 0.951 0.095 0.19 4.76 × 10−3 1.1 7.10 × 10−6
Spleen 0.1 0.01 0.02 5.00 × 10−4 0.05 7.47 × 10−7
Heart 0.133 0.007 0.019 6.65 × 10−4 0.28 9.93 × 10−7
Kidney 0.298 0.03 0.101 1.49 × 10−3 0.8 2.22 × 10−6
Skin 2.94 0.2 0.999 1.47 × 10−2 1.21 2.19 × 10−5
Muscle 7.924 0.15 1.032 3.96 × 10−2 0.8 5.92 × 10−5