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. Author manuscript; available in PMC: 2013 Jul 30.
Published in final edited form as: Bioorg Med Chem. 2012 Mar 12;20(9):3009–3015. doi: 10.1016/j.bmc.2012.03.004

Scheme 1.

Scheme 1

Synthesis of 2′-deoxyguanosine analogue 5. Reagents and conditions: (a) TMSCl, pyridine then isobutyryl chloride, 24 h; (b) 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane, pyridine, rt, 24 h; (c) phenyl chlorothionoformate, DMAP, rt, 24 h; (d) AIBN, Bu3SnH, toluene, reflux, 6 h; (e) (i) 1 M TBAF, THF, rt, 4 h; (ii) methanolic ammonia, rt.